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Seeing Deeper: An Interview with Lihong Wang

03-10-17

Using a combination of light and sound, Professor Lihong Wang is noninvasively peering deeper inside biological tissues than previously possible. His team uses three-dimensional photoacoustic microscopy and functional photoacoustic computed tomography to generate detailed color images of tumors and other structures inside the body. [Interview with Prof. Wang]

Tags: EE research highlights MedE Lihong Wang

The Future is Flat (For Lenses)

12-22-16

Andrei Faraon, Assistant Professor of Applied Physics and Materials Science, and colleagues have developed a system of flat optical lenses that can be easily mass-produced and integrated with image sensors, paving the way for cheaper and lighter cameras in everything from cell phones to medical devices. [Caltech story]

Tags: APhMS research highlights MedE Andrei Faraon

Building Better Batteries

12-19-16

Julia R. Greer, Professor of Materials Science and Mechanics, and colleagues have measured for the first time the strength of lithium metal at the nano- and microscale, a discovery with important implications for suppressing dendrite formation and improving lithium-ion batteries.  [Caltech story]

Tags: APhMS research highlights MedE MCE Julia Greer

Noise-Canceling Optics

10-10-16

Changhuei Yang, Professor of Electrical Engineering, Bioengineering, and Medical Engineering, and colleagues have created the visual analogue of noise-canceling headphones—a camera system that can obtain images of objects obscured by murky media, such as fog or clouds, by canceling out the glare. Their device selectively cancels the scattered light, leaving only the light that is reflected or bounced off the objects and has slipped back through the murk unmolested. [Caltech story]

Tags: EE research highlights Changhuei Yang MedE

Your Future is Calling

10-03-16

Professor Morteza Gharib was one of the speakers at a recent symposium celebrating the Caltech–City of Hope Biomedical Research Initiative which provides seed grants to accelerate the development of basic scientific research and its translation into biomedical applications. Professor Gharib’s presentation was focused on measuring the ejection fraction, the fraction of blood that is ejected from the heart with each heartbeat. The group has designed a small piece of hardware that can connect to an iPhone and calculate a patient's ejection fraction—for less than $8. The device, called Vivio, gives comparable results to a cardiac magnetic resonance imaging, the gold standard in the medical industry for measuring heart health. [Caltech story]

Tags: research highlights GALCIT MedE Morteza Gharib

Tiny Diatoms Boast Enormous Strength

02-08-16

Researchers in the lab of Julia R. Greer, Professor of Materials Science and Mechanics, have recently found that diatom shells have the highest specific strength—the strength at which a structure breaks with respect to its density—of any known biological material, including bone, antlers, and teeth. [Caltech story]

Tags: APhMS research highlights MedE MCE Julia Greer

Popping Microbubbles Help Focus Light Inside the Body

12-03-15

Changhuei Yang, Professor of Electrical Engineering, Bioengineering, and Medical Engineering, and his postdoctoral colleague Dr. Haowen Ruan have developed a novel technique called time-reversed ultrasound microbubble encoded (TRUME) that uses gas-filled microbubbles to focus light inside tissue. "Ultrasound and X-ray techniques can only detect cancer after it forms a mass," Yang says. "But with optical focusing, you could catch cancerous cells while they are undergoing biochemical changes but before they undergo morphological changes." [Caltech story]

Tags: EE Changhuei Yang MedE health research highlight postdocs

Cancer Treatment in a Painless Patch

11-05-15

Mechanical engineering undergraduate student, Teo Wilkening, spent this past summer working with Professor Gharib to test the preliminary design for an alternative—and possibly much less painful—method of chemotherapy drug delivery through a patch. To avoid the pain caused by the large needle traditionally used for such an intravenous injection, the team envisioned a patch containing hundreds of micrometer-scale needles, too small in diameter to be sensed by the nerves in the skin. [Caltech story]

Tags: GALCIT MedE MCE Morteza Gharib research highlight Teo Wilkening

Atomic Fractals in Metallic Glasses

09-18-15

Julia R. Greer, Professor of Materials Science and Mechanics, and colleagues including graduate student David Chen have shown that metallic glasses has an atomic-level structure although it differs from the periodic lattices that characterize crystalline metals. "Our group has solved this paradox by showing that atoms are only arranged fractally up to a certain scale," Greer says. "Larger than that scale, clusters of atoms are packed randomly and tightly, making a fully dense material, just like a regular metal. So we can have something that is both fractal and fully dense." [Caltech story]

Tags: APhMS research highlights MedE MCE Julia Greer David Chen

New, Ultrathin Optical Devices Shape Light in Exotic Ways

09-03-15

Andrei Faraon, Assistant Professor of Applied Physics and Materials Science, and colleagues have created silicon nanopillars devices capable of manipulating light in ways that are very difficult or impossible to achieve with conventional optical components. The devices are precisely arranged into a honeycomb pattern to create a "metasurface" that can control the paths and properties of passing light waves. Professor Faraon describes, "this new technology is very similar to the one used to print semiconductor chips onto silicon wafers, so you could conceivably manufacture millions of systems such as microscopes or cameras at a time." [Caltech story] [BBC video clip]

Tags: APhMS research highlights MedE Andrei Faraon