Professor Wang Advances Photoacoustic Imaging Technology
02-25-20
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed variants of photoacoustic imaging that can show organs moving in real time, develop three-dimensional (3-D) images of internal body parts, and even differentiate cancerous cells from healthy cells. Photoacoustic imaging, a technique for examining living materials through the use of laser light and ultrasonic sound waves, has many potential applications in medicine because of its ability to show everything from organs to blood vessels to tumors. Wang has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [Caltech story]
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Professor Wang Develops World's Fastest Camera
01-21-20
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed the world's fastest camera, a device capable of taking 10 trillion pictures per second. It's so fast that it can even capture light traveling in slow motion. "What we've done is to adapt standard phase-contrast microscopy so that it provides very fast imaging, which allows us to image ultrafast phenomena in transparent materials," says Wang. [Caltech story]
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"Neural Lander" Uses AI to Land Drones Smoothly
05-23-19
Professors Chung, Anandkumar, and Yue have teamed up to develop a system that uses a deep neural network to help autonomous drones "learn" how to land more safely and quickly, while gobbling up less power. The system they have created, dubbed the "Neural Lander," is a learning-based controller that tracks the position and speed of the drone, and modifies its landing trajectory and rotor speed accordingly to achieve the smoothest possible landing. The new system could prove crucial to projects currently under development at CAST, including an autonomous medical transport that could land in difficult-to-reach locations (such as a gridlocked traffic). "The importance of being able to land swiftly and smoothly when transporting an injured individual cannot be overstated," says Professor Gharib who is the director of CAST; and one of the lead researchers of the air ambulance project. [Caltech story]
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Morteza Gharib
Yisong Yue
Soon-Jo Chung
Animashree Anandkumar
Lasers Aim to Replace Scalpels in Cutting-Edge Biopsy Technique
05-16-19
Professor Lihong Wang and Postdoctoral Scholar Dr. Junhui Shi have developed a new imaging technique that uses pulses from two kinds of lasers to take pictures of microscopic biological structures. This new approach, called ultraviolet-localized mid-infrared photoacoustic microscopy, or ULM-PAM, develops images of the microscopic structures found in a piece of tissue by bombarding the sample with both infrared and ultraviolet laser light. "Because ultraviolet light and infrared have different properties, we had to find special mirrors and glass that could focus both," Dr. Shi says. "And because no camera exists that can see both, we had to develop ways to see if they were correctly focused." [Caltech story]
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Laser Technology Helps Researchers Scrutinize Cancer Cells
04-01-19
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues are using photoacoustic microscopy (PAM) to improve on an existing technology for measuring the oxygen-consumption rate (OCR). This new method allows the researchers to determine how oxygenated a sample of blood is by "listening" to the sound it makes when illuminated by the laser. Professor Wang calls this single-cell metabolic photoacoustic microscopy, or SCM-PAM. [Caltech story]
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Lihong Wang
